Peer-Reviewed Publications


2016

Alterations in connectivity on functional magnetic resonance imaging with provocation of lower urinary tract symptoms: a MAPP research network feasibility study of urological chronic pelvic pain syndromes.

This study found that MRIs performed on patients with full bladders can detect differences in brain activity between people with and without urologic chronic pelvic pain.

 

Assessment of the lower urinary tract microbiota during symptom flare in women with urologic chronic pelvic pain syndrome: a MAPP Network Study. 

 

Bladder Distension Increases Blood Flow in Pain Related Brain Structures in Subjects with Interstitial Cystitis.

This article discusses the similarities and differences in blood flow in the brains of healthy controls and patients with urologic chronic pelvic pain.

 

Inflammation and symptom change in interstitial cystitis or bladder pain syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network

This article found a number of molecules which signal inflammation may be linked to symptom changes in IC/BPS.

 

Multisite, multimodal neuroimaging of chronic urological pelvic pain: methodology of the MAPP research network. 

This article discusses the neuroimaging (MRI) procedures used in MAPP, and how study sites across the country collaborated to collect the best data.

 

Pain and Urinary Symptoms Should Not be Combined into a Single Score: Psychometric Findings from the MAPP Research Network.

This article discusses how pain and urinary symptoms should be looked at separately, rather than combined.

 

Symptom Variability and Early Symptom Regression in the MAPP Study, a Prospective Study of Urologic Chronic Pelvic Pain Syndrome.

This article discusses symptom variability in men and women.

 

Urinary Metabolomics Identifies a Molecular Correlate of Interstitial Cystitis/Bladder Pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort

This study found that there may be a number of small molecules that contribute to IC/BPS symptoms.


2015

Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. 

 

Animal models of urologic chronic pelvic pain syndromes: findings from the multidisciplinary approach to the study of chronic pelvic pain research network. 

This article discusses how MAPP Network investigators determined what symptoms they would prioritize when using rodents to study IC/BPS.

 

Brain white matter abnormalities in female interstitial cystitis/bladder pain syndrome: a MAPP network neuroimaging study.

This article provides the first description of differences in the brains of females with chronic pelvic pain.

 

Changes in symptoms during urologic chronic pelvic pain syndrome flares: findings from one site of the MAPP Research Network.

This article reports chronic pelvic pain patients’ descriptions of their symptoms during a flare.

 

Comparison of baseline urologic symptoms in men and women in the MAPP Research Cohort.

This article discusses the similarities and differences between chronic pelvic pain symptoms in men and women.

 

Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/bladder pain syndrome.

This article supports the notion that changes in brain structure play a role in mood and sensitivity to pain.

 

Painful bladder filling and painful urgency are distinct characteristics in men and women with urological chronic pelvic pain syndromes: a MAPP research network study. 

 

Relationship between chronic nonurological associated somatic symptoms and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study.

This article discusses how urologic and nonurologic symptoms may be related in chronic pelvic pain conditions

 

Search for microorganisms in men with urologic chronic pelvic pain syndrome: a culture-independent analysis in the MAPP Research Network.

This article discusses the presence of a certain microbe in urine samples of males with chronic pelvic pain

 

Toll-like receptor 4 and comorbid pain in interstitial cystitis/bladder pain syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. 

 

The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network. A resting-state study from the MAPP research network. 

This study found significant differences in connections in the brain linked to pain, self-referential thought, emotion, and movement between women with and without UCPPS.

 

Unique microstructural changes in the brain associated with urological chronic pelvic pain syndrome (UCPPS) revealed by diffusion tensor MRI, super-resolution track density imaging, and statistical parameter mapping: a MAPP metwork neuroimaging study. 

 

Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network.

This article describes the impact chronic pelvic pain “flares” have on female participants’ lives.

 

Widespread psychosocial difficulties in men and women with urologic chronic pelvic pain syndromes: case-control findings from the multidisciplinary approach to the study of chronic pelvic pain research network. 


2014

Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome.

This article discusses findings that suggest a difference in brain activity between females with urologic chronic pelvic pain and healthy controls. 

 

Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.

This article discusses the role of certain brain structures in processing bladder pain.

 

Evidence for overlap between urological and nonurological unexplained clinical conditions.

This article discusses the considerable overlap between chronic pain and fatigue diagnoses.

 

Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: associations with painful symptoms.

This article discusses findings that suggest inflammation could be linked to chronic pelvic pain symptoms in females

 

The MAPP research network: design, patient characterization, and operations.

This article talks about the MAPP Network's approach to research and the study that was completed in June of 2014. 

 

The MAPP research network: a novel study of urological pelvic pain syndromes.

This article talks about how the MAPP Research Network is set up and the novel approach to studying urologic chronic pelvic pain syndromes. 

 

 

 

More publications are on the way, so stay tuned!