Symptom Pattern Study



Who is eligible?

We are currently recruiting individuals who:

  • Are 18 years or older
  • Have a diagnosis from your doctor of either:
    • Interstitial Cystitis/Bladder Pain Syndrome
    • Chronic Prostatitis/Chronic Pelvic Pain Syndrome

We have limited availability for healthy volunteers: Healthy Volunteer Information

 

What could exclude me from participating?

Below are a few reasons why some individuals may not be able to participate. If you are unsure about whether you fall into a category below, feel free to get in touch with us.

This study is not the best fit if you:

  • Have an active, ongoing autoimmune or infectious disorder.
  • Have been diagnosed with a pelvic malignancy.
  • Are receiving treatment for cancer (not including skin cancer).
  • Have a history of cystitis (inflammation of the bladder) caused by chemotherapy or radiation.
  • Have an ongoing, symptomatic urethral stricture.
  • Have had a cystectomy (your bladder removed) or cystoplasty (your bladder enlarged, partially replaced, or completely replaced).
  • Have a neurological disease or disorder that affects the bladder or a bowel fistula.
  • (For males) Have been diagnosed with unilateral orchalgia, without pelvic symptoms.
  • (For males) Have had any of these procedures: a transurethral microwave thermotherapy, transurethral needle ablation, balloon dilation, prostate cryo-surgery, or prostate laser surgery.
  • Have any implants or conditions that would prevent you from having an MRI scan, including claustrophobia. If you have a neurostimulator you may still be eligible.

We will delay the beginning of your participation if you:

  • Have had a urinary tract infection in the 6 weeks prior to your visit.
  • Have blood your urine that has not been evaluated by your doctor.
  • (For females) Are currently pregnant, or have given birth in the 3 months prior to your visit.
  • (For females) Have had urethritis or vaginitis (a yeast infection) in the 6 weeks prior to your visit.
  • (For males) Have had epididymitis in the 6 weeks prior to your visit. 
  • (For males) Have had a prostate biopsy or Transurethral Resection of the Prostate (TURP) procedure in the 3 months prior to your visit.

Length of Participation

We'll ask you to participate for 36 months.

Schedule of Study Tasks (click on image for full view)

Study Tasks:

Participation includes:

  • In-person clinic visits at our Seattle location
    • One enrollment visit (2-3 hours) that includes:
      • Eligibility confirmation
      • Questionnaires
      • A pelvic exam
      • Urine collections
    • Four in-depth visits (6-7 hours) that include:
      • Questionnaires
      • A blood draw
      • Urine collections
      • A pelvic exam (only at select visits)
      • MRI scans of your brain
      • Sensory testing tasks
    • Three optional sample collection visits (1.5 - 2 hours) that include:
      • Questionnaires
      • A blood draw
      • Urine collections
  • Monthly online questionnaires
  • A series of at-home saliva collections

ATLAS Modules

Throughout the study we will also be keeping in touch with you about what medications or therapies you are using to treat your pelvic pain symptoms. If you add a treatment it may trigger an "ATLAS module." A module is 12-weeks long and includes:

  • Two in-depth visits (6-7 hours), scheduled so that:
    • Your first visit is  ideally before you start your newly added treatment.
    • The second visit is 12 weeks after you started the treatment.
  • Bi-weekly online questionnaires. These replace your regular monthly questionnaires.

Getting Started!

You can read more about each study procedure by reading our study consent form. This document is what you would sign if you are eligible and decide to participate. You can also contact a research coordinator to talk about the study or if you have questions about the consent form. 

To get started take a quick eligibility survey. We use your answers to see whether this study is a good fit for you. Your answers are kept confidential. You can also contact a research coordinator to complete these questions by phone.